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Version: 17.06d (Release date: 2017-06-26)
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Radium Ra 223 Dichloride (Code C62535)

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Terms & Properties

Preferred Name: Radium Ra 223 Dichloride

Definition: A radiopharmaceutical composed of the dichloride salt of the alpha-emitting isotope radium Ra 223, with antineoplastic activity. Like calcium, radium targets bone tissue and preferentially accumulates in osteoblastic lesions, such as those seen in areas of bone metastases. Radium Ra 223 forms complexes with hydroxyapatite and becomes incorporated into the bone matrix. The radioisotope Ra 223 kills bone cancer cells through local emission of high energy alpha particles, causing DNA double-strand breaks and tumor regression in the skeleton. The short range effects of alpha emission allows for localized DNA damage with limited toxicity to nearby healthy bone tissue.

Display Name: Radium Ra 223 Dichloride

Label: Radium Ra 223 Dichloride

NCI Thesaurus Code: C62535 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C3651269  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Alpharadin
BAY88-8223
BAY 88-8223
Radium-223 Dichloride
Radium 223 Dichloride
RADIUM CHLORIDE RA-223
Radium Ra 223 Dichloride
Xofigo

External Source Codes: 
CAS Registry Number 444811-40-9 (see NLM ChemIDplus info)
FDA UNII Code RJ00KV3VTG
PDQ Closed Trial Search ID 749662
PDQ Open Trial Search ID 749662 (check for NCI PDQ open clinical trial info)
UMLS CUI C3651269

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula 2Cl.Ra
code C62535
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Radium-223
Semantic_Type Element, Ion, or Isotope
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C62535

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