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Version: 16.11d (Release date: 2016-11-28)
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Human Monoclonal Antibody 216 (Code C62532)

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Terms & Properties

Preferred Name: Human Monoclonal Antibody 216

Definition: A naturally-occurring human IgM monoclonal antibody with potential antineoplastic activity. Human monoclonal antibody 216, derived from the gene VH4-34, binds to the glycosylated epitope CDIM on the surface of both malignant and normal B cells. Upon binding to B cells, this antibody may crosslink two or more CDIM molecules, resulting in the formation of cell membrane pores, the disruption of cell membrane integrity, and B cell lysis; this mechanism of antibody-mediated cell death is direct and does not involve mechanisms of complement-mediated cytotoxicity or antibody-dependent cell-mediated cytotoxicity (ADCC). CDIM is the glyco-moiety of a 75kD B-cell cell surface glycoprotein.

Display Name: Human Monoclonal Antibody 216

Label: Human Monoclonal Antibody 216

NCI Thesaurus Code: C62532 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1831869  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Human Monoclonal Antibody 216
MoAb 216

External Source Codes: 
PDQ Closed Trial Search ID 488467
PDQ Open Trial Search ID 488467 (check for NCI PDQ open clinical trial info)
UMLS CUI C1831869

Other Properties:
Name Value (qualifiers indented underneath)
code C62532
Contributing_Source CTRP
Legacy_Concept_Name Human_Monoclonal_Antibody_216
Semantic_Type Amino Acid, Peptide, or Protein

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C62532

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