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Version: 17.06d (Release date: 2017-06-26)
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Blinatumomab (Code C62528)

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Terms & Properties

Preferred Name: Blinatumomab

Definition: A recombinant, single-chain, anti-CD19/anti-CD3 bispecific monoclonal antibody with potential immunostimulating and antineoplastic activities. Blinatumomab possesses two antigen-recognition sites, one for the CD3 complex, a group of T cell surface glycoproteins that complex with the T cell receptor (TCR), and one for CD19, a tumor-associated antigen (TAA) overexpressed on the surface of B cells. This bispecific monoclonal antibody brings CD19-expressing tumor B-cells and cytotoxic T lymphocytes (CTLs) and helper T lymphocytes (HTLs) together, which may result in the CTL- and HTL-mediated cell death of CD19-expressing B-lymphocytes.

Display Name: Blinatumomab

Label: Blinatumomab

NCI Thesaurus Code: C62528 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C3853839  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Anti-CD19/Anti-CD3 Recombinant Bispecific Monoclonal Antibody MT103
Anti-CD19 x Anti-CD3 Bispecific Monoclonal Antibody
Blinatumomab
BLINATUMOMAB
Blincyto
MEDI-538
MT-103

External Source Codes: 
CAS Registry Number 853426-35-4 (see NLM ChemIDplus info)
FDA UNII Code 4FR53SIF3A
PDQ Closed Trial Search ID 487684
PDQ Open Trial Search ID 487684 (check for NCI PDQ open clinical trial info)
UMLS CUI C3853839

Other Properties:
     Name Value (qualifiers indented underneath)
code C62528
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Anti-CD19_Anti-CD3_Bispecific_Monoclonal_Antibody
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Immunologic Factor

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C62528

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