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Version: 17.06d (Release date: 2017-06-26)
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Adenovirus Encoding Rat HER-2/neu (Code C62527)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Adenovirus Encoding Rat HER-2/neu

Definition: A replication-defective oncolytic adenovirus, encoding rat Her-2/neu (ErbB-2), with potential antineoplastic activity. Upon administration, adenovirus encoding rat HER-2/neu may induce an immune response against tumor cells expressing the HER-2/neu antigen, which may result in the immune-mediated inhibition of tumor cell proliferation and tumor cell death. Her-2/neu, a tumor-associated antigen and member of the epidermal growth factor receptor (EGFR) family of tyrosine kinases, is overexpressed in various tumor cell types.

Label: Adenovirus Encoding Rat HER-2/neu

NCI Thesaurus Code: C62527 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1831867  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Adenovirus Encoding Rat HER-2/neu

External Source Codes: 
PDQ Closed Trial Search ID 488459
PDQ Open Trial Search ID 488459 (check for NCI PDQ open clinical trial info)
UMLS CUI C1831867

Other Properties:
     Name Value (qualifiers indented underneath)
code C62527
Legacy_Concept_Name Adenovirus_Encoding_Rat_Her-2_neu
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C62527

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