skip navigation links
National Cancer Institute
EVS Logo NCI Term Browser Enterprise Vocabulary Services
Terminologies Value Sets Mappings
Version: 17.06d (Release date: 2017-06-26)
SearchBox Top
SearchBox Bottom
Iniparib (Code C62526)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Iniparib

Definition: A small molecule iodobenzamide with potential cytotoxic and antineoplastic activities. Although the mechanism of action is unknown, iniparib appears to be cytotoxic in cells with DNA alterations or DNA damage, like that found in tumor cells with mutations in the ataxia telangiectasia mutated (ATM) gene. ATM encodes a serine/threonine protein kinase and mutations of the gene are associated with ataxia telangiectasia and contribute to certain cancers such as T-cell acute lymphoblastic leukemia, B-cell chronic lymphocytic leukemia and B-cell non-Hodgkin lymphomas.

NCI-GLOSS Definition: A substance being studied in the treatment of breast cancers caused by mutations (changes) in the BRCA1 and BRCA2 genes. It is also being studied in the treatment of other types of cancer. It blocks an enzyme involved in many functions of the cell, including the repair of DNA damage. DNA damage may be caused by normal cell actions, UV light, some anticancer drugs, and radiation used to treat cancer. BSI-201 may cause cancer cells to die. It is a type of poly(ADP-ribose) polymerase inhibitor.

Display Name: Iniparib

Label: Iniparib

NCI Thesaurus Code: C62526 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0291482  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
4-Iodo-3-Nitrobenzamide
BSI-201
Iniparib
iniparib
INIPARIB
PARP-1 inhibitor BSI-201
PARP-1 Inhibitor BSI-201
SAR240550

External Source Codes: 
CAS Registry Number 160003-66-7 (see NLM ChemIDplus info)
CAS Registry Number 937799-96-7 (see NLM ChemIDplus info)
FDA UNII Code 2ZWI7KHK8F
PDQ Closed Trial Search ID 488465
PDQ Open Trial Search ID 488465 (check for NCI PDQ open clinical trial info)
UMLS CUI C0291482

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C7H5IN2O3
code C62526
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name BSI-201
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C62526

Mainbox Bottom