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Version: 17.06d (Release date: 2017-06-26)
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Vintafolide (Code C62525)

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Terms & Properties

Preferred Name: Vintafolide

Definition: A water-soluble, folate-receptor-targeted conjugate of folate and the vinca alkaloid desacetylvinblastine monohydrazide (DAVLBH) with potential antineoplastic activity. The folate moiety of vintafolide binds to folic acid receptors on the tumor cell surface and the agent is internalized via folate receptor-mediated endocytosis, delivering the tubulin-binding DAVLBH moiety directly into the tumor cell; DAVLBH binding to tubulin results in the disruption of microtubule assembly-disassembly dynamics, cell cycle arrest, and tumor cell apoptosis. Folic acid receptors are frequently upregulated on the surfaces of many tumor cell types. DAVLBH is a derivative of the natural product vinblastine.

Display Name: Vintafolide

Label: Vintafolide

NCI Thesaurus Code: C62525 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1831870  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
EC145
Folate-Vinca Alkaloid Conjugate EC145
Vintafolide
VINTAFOLIDE

External Source Codes: 
CAS Registry Number 742092-03-1 (see NLM ChemIDplus info)
FDA UNII Code 36O410ZD4I
PDQ Closed Trial Search ID 488470
PDQ Open Trial Search ID 488470 (check for NCI PDQ open clinical trial info)
UMLS CUI C1831870

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C86H109N21O26S2
code C62525
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name EC145
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C62525

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