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National Cancer Institute
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Version: 16.10e (Release date: 2016-10-31)
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Seneca Valley Virus-001 (Code C62524)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Seneca Valley Virus-001

Definition: A replication-competent oncolytic picornavirus with potential antineoplastic activity. Administered systemically, Seneca Valley virus-001 specifically targets and infects tumor cells with neuroendocrine characteristics. Upon infection, this agent replicates intracellularly, resulting in tumor cell lysis and reduced tumor cell proliferation. The selective tropism of virus replication may involve receptor-mediated internalization.

NCI-GLOSS Definition: A virus being studied in the treatment of neuroendocrine tumors and other types of cancer. Neuroendocrine tumors form from cells that release hormones in response to a signal from the nervous system. The virus infects and breaks down these tumor cells but not normal cells. It is a type of oncolytic virus.

Display Name: Seneca Valley Virus-001

Label: Seneca Valley Virus-001

NCI Thesaurus Code: C62524 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL365090  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
NTX-010
Seneca Valley Virus-001
Seneca Valley virus-001
SVV-001

External Source Codes: 
PDQ Closed Trial Search ID 488482
PDQ Open Trial Search ID 488482 (check for NCI PDQ open clinical trial info)
NCI META CUI CL365090

Other Properties:
Name Value (qualifiers indented underneath)
code C62524
Contributing_Source CTRP
Legacy_Concept_Name Seneca_Valley_Virus
Semantic_Type Pharmacologic Substance
Semantic_Type Virus

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C62524

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