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National Cancer Institute
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Version: 17.06d (Release date: 2017-06-26)
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CDK Inhibitor SNS-032 (Code C62523)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: CDK Inhibitor SNS-032

Definition: A small aminothiazole molecule and cyclin dependent kinase (CDK) inhibitor with potential antineoplastic activity. SNS-032 binds to and prevents the phosphorylation of cyclin-dependent kinases, especially CDK2, 7, and 9 that regulate cell cycle progression. Inhibition of CDKs leads to cell cycle arrest and induces apoptosis. As a result, this agent causes cytotoxicity and prevents further tumor cell growth.

Label: CDK Inhibitor SNS-032

NCI Thesaurus Code: C62523 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1451099  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
BMS-387032
CDK Inhibitor SNS-032
SNS-032

External Source Codes: 
PDQ Closed Trial Search ID 488948
PDQ Open Trial Search ID 488948 (check for NCI PDQ open clinical trial info)
UMLS CUI C1451099

Other Properties:
     Name Value (qualifiers indented underneath)
code C62523
Legacy_Concept_Name SNS-032
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C62523

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