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Version: 17.06d (Release date: 2017-06-26)
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Mocetinostat (Code C62521)

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Terms & Properties

Preferred Name: Mocetinostat

Definition: A rationally designed, orally available, Class 1-selective, small molecule, 2-aminobenzamide HDAC inhibitor with potential antineoplastic activity. Mocetinostat binds to and inhibits Class 1 isoforms of HDAC, specifically HDAC 1, 2 and 3, which may result in epigenetic changes in tumor cells and so tumor cell death; although the exact mechanism has yet to be defined, tumor cell death may occur through the induction of apoptosis, differentiation, cell cycle arrest, inhibition of DNA repair, upregulation of tumor suppressors, down regulation of growth factors, oxidative stress, and autophagy, among others. Overexpression of Class I HDACs 1, 2 and 3 has been found in many tumors and has been correlated with a poor prognosis.

NCI-GLOSS Definition: A substance being studied in the treatment of several types of cancer. It blocks enzymes needed for cell division and may kill cancer cells. It is a type of histone deacetylase (HDAC) inhibitor.

Display Name: Mocetinostat

Label: Mocetinostat

NCI Thesaurus Code: C62521 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2002471  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Benzamide, N-(2-aminophenyl)-4-[[[4-(3-pyridinyl)-2-pyrimidinyl]amino]methyl]-
MG-0103
MGCD0103
Mocetinostat
mocetinostat
MOCETINOSTAT
N-(2-aminophenyl)-4-((4-pyridin-3-ylpyrimidin-2-ylamino)methyl)benzamide

External Source Codes: 
CAS Registry Number 726169-73-9 (see NLM ChemIDplus info)
FDA UNII Code A6GWB8T96J
PDQ Closed Trial Search ID 486941
PDQ Open Trial Search ID 486941 (check for NCI PDQ open clinical trial info)
UMLS CUI C2002471

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C23H20N6O
code C62521
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name MGCD0103
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C62521

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