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Version: 16.11d (Release date: 2016-11-28)
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18F-Fluoroazomycin Arabinoside (Code C62520)

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Terms & Properties

Preferred Name: 18F-Fluoroazomycin Arabinoside

Definition: A radiofluorinated 2-nitroimidazole derivative with positron-emitting radioisotope activity. Upon administration, 18F-fluoroazomycin arabinoside is reduced under hypoxic conditions in the tumor microenvironment to a reactive species that covalently binds to intracellular macromolecules, providing a quantitative measure of viable hypoxic tissue when imaged with positron emission tomography. Compared to 18F-misonidazole, 18F-fluoroazomycin arabinoside has a lower octanol:water partition coefficient; it therefore has less tendency to accumulate in lipophilic tissues and exhibits a faster renal clearance, which may result in improved imaging of hypoxic tissue.

Label: 18F-Fluoroazomycin Arabinoside

NCI Thesaurus Code: C62520 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1566975  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
18F-FAZA
18F-Fluoroazomycin Arabinoside

External Source Codes: 
PDQ Closed Trial Search ID 486925
PDQ Open Trial Search ID 486925 (check for NCI PDQ open clinical trial info)
UMLS CUI C1566975

Other Properties:
Name Value (qualifiers indented underneath)
code C62520
Legacy_Concept_Name _18F-Fluoroazomycin_Arabinoside
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C62520

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