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Version: 17.06d (Release date: 2017-06-26)
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Phosphorodiamidate Morpholino Oligomer AVI-4126 (Code C62518)

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Terms & Properties

Preferred Name: Phosphorodiamidate Morpholino Oligomer AVI-4126

Definition: A c-Myc antisense phosphorodiamidate morpholino oligomer (PMO) with potential antineoplastic activity. Phosphorodiamidate morpholino oligomer AVI-4126 binds to c-Myc mRNA and blocks its translation, which may result in the death of tumor cells overexpressing c-Myc. Differing from traditional antisense oligodeoxynucleotides (ODNs), neutrally charged PMOs are composed of subunits of nucleic acid bases linked to a synthetic backbone and, so, are less prone to enzymatic degradation. c-Myc, a proto-oncogene overexpressed in a variety of cancers, is involved in cellular proliferation, differentiation, and apoptosis.

Label: Phosphorodiamidate Morpholino Oligomer AVI-4126

NCI Thesaurus Code: C62518 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1450425  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
AVI-4126
Phosphorodiamidate Morpholino Oligomer AVI-4126
PMO AVI-4126

External Source Codes: 
PDQ Closed Trial Search ID 496940
PDQ Open Trial Search ID 496940 (check for NCI PDQ open clinical trial info)
UMLS CUI C1450425

Other Properties:
     Name Value (qualifiers indented underneath)
code C62518
Legacy_Concept_Name AVI-4126
Semantic_Type Nucleic Acid, Nucleoside, or Nucleotide
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C62518

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