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Version: 17.06d (Release date: 2017-06-26)
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Hsp90 Inhibitor BIIB021 (Code C62517)

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Terms & Properties

Preferred Name: Hsp90 Inhibitor BIIB021

Definition: An orally active inhibitor of heat shock protein 90 (HSP90) with potential antineoplastic activity. HSP90, a chaperon protein upregulated in a variety of tumor cells, regulates the folding and degradation of many oncogenic signaling proteins. HSP90 inhibitor BIIB021 specifically blocks active HSP90, thereby inhibiting its chaperon function and promoting the degradation of oncogenic signaling proteins involved in tumor cell proliferation and survival. As a result, CNF2024 has the potential to inhibit the growth of a wide range of cancer cells in both solid tumors and blood-based cancers.

Display Name: Hsp90 Inhibitor BIIB021

Label: Hsp90 Inhibitor BIIB021

NCI Thesaurus Code: C62517 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1831929  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
BIIB-021
BIIB021
CNF2024
Hsp90 Antagonist CNF2024
Hsp90 Inhibitor BIIB021

External Source Codes: 
CAS Registry Number 848695-25-0 (see NLM ChemIDplus info)
FDA UNII Code 851B9FQ7Q0
PDQ Closed Trial Search ID 497050
PDQ Open Trial Search ID 497050 (check for NCI PDQ open clinical trial info)
UMLS CUI C1831929

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C14H15ClN6O
code C62517
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name CNF2024
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C62517

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