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Version: 16.11d (Release date: 2016-11-28)
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Bis(choline)tetrathiomolybdate (Code C62514)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Bis(choline)tetrathiomolybdate

Definition: An orally active second generation tetrathiomolybdate analog with anti-angiogenic and antineoplastic activities. ATN-224 selectively chelates the copper ion in superoxide dismutase 1 (SOD1) in endothelial cells, thereby depleting SOD1 of copper and inhibiting its activity. Inhibition of SOD1 interferes with the activation of several signal transduction pathways required for cellular proliferation and angiogenesis, including those mediated by ERK1/2 and FAK and Src kinases. This results in an inhibition of cell proliferation and angiogenesis as well as induction of apoptosis.

NCI-GLOSS Definition: A substance being studied in the treatment of cancer. It may prevent the growth of new blood vessels that tumors need to grow. ATN-224 also blocks enzymes that cells need to divide and grow, and it may kill cancer cells. It is a type of antiangiogenesis agent and a type of superoxide dismutase inhibitor.

Label: Bis(choline)tetrathiomolybdate

NCI Thesaurus Code: C62514 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1831930  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
ATN-224
BIS(CHOLINE)TETRATHIOMOLYBDATE
Bis(choline)tetrathiomolybdate
Ethanaminium, 2-Hydroxy-N,N,N-Trimethyl-, (T-4)-Tetrathioxomolybdate(2-) (2:1)
SOD1 Inhibitor ATN-224
SOD1 inhibitor ATN-224

External Source Codes: 
CAS Registry Number 649749-10-0 (see NLM ChemIDplus info)
FDA UNII Code FD57A79R4P
PDQ Closed Trial Search ID 500040
PDQ Open Trial Search ID 500040 (check for NCI PDQ open clinical trial info)
UMLS CUI C1831930

Other Properties:
Name Value (qualifiers indented underneath)
Chemical_Formula 2C5H14NO.MoS4
code C62514
Contributing_Source FDA
Legacy_Concept_Name ATN-224
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C62514

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