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Version: 17.06d (Release date: 2017-06-26)
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Mogamulizumab (Code C62510)

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Terms & Properties

Preferred Name: Mogamulizumab

Definition: A humanized monoclonal antibody directed against C-C chemokine receptor 4 (CCR4) with potential anti-inflammatory and antineoplastic activities. Mogamulizumab selectively binds to and blocks the activity of CCR4, which may inhibit CCR4-mediated signal transduction pathways and, so, chemokine-mediated cellular migration and proliferation of T cells, and chemokine-mediated angiogenesis. In addition, this agent may induce antibody-dependent cell-mediated cytotoxicity (ADCC) against CCR4-positive T cells. CCR4, a G-coupled-protein receptor for C-C chemokines such MIP-1, RANTES, TARC and MCP-1, is expressed on the surfaces of some types of T cells, endothelial cells, and some types of neurons. CCR4, also known as CD194, may be overexpressed on adult T-cell lymphoma (ATL) and peripheral T-cell lymphoma (PTCL) cells.

Display Name: Mogamulizumab

Label: Mogamulizumab

NCI Thesaurus Code: C62510 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2987603  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Immunoglobulin G1, Anti-(CC Chemokine Receptor CCR4) (Human-Mouse Monoclonal KW-0761 Heavy Chain), Disulfide With Human-Mouse Monoclonal KW-0761 Kappa-Chain, Dimer

External Source Codes: 
CAS Registry Number 1159266-37-1 (see NLM ChemIDplus info)
FDA UNII Code YI437801BE
PDQ Closed Trial Search ID 500479
PDQ Open Trial Search ID 500479 (check for NCI PDQ open clinical trial info)
UMLS CUI C2987603

Other Properties:
     Name Value (qualifiers indented underneath)
code C62510
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name KW-0761
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Immunologic Factor

Additional Concept Data: 
Defined Fully by Roles: No  


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