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National Cancer Institute
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Version: 17.06d (Release date: 2017-06-26)
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IMP321 (Code C62509)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: IMP321

Definition: A T-cell immunostimulatory factor, derived from the soluble form of the lymphocyte-activation gene 3 (LAG-3) protein, with potential antineoplastic activity. Upon administration, alone or in combination with tumor antigens, IMP321 binds with high affinity to MHC class II molecules expressed by dendritic cells (DC), potentially resulting in DC maturation, DC migration to lymph nodes, enhanced DC cross-presentation of antigens to T cells, and antitumor cytotoxic T cell responses.

Display Name: IMP321

Label: IMP321

NCI Thesaurus Code: C62509 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1739076  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Immufact
IMP321

External Source Codes: 
PDQ Closed Trial Search ID 496939
PDQ Open Trial Search ID 496939 (check for NCI PDQ open clinical trial info)
UMLS CUI C1739076

Other Properties:
     Name Value (qualifiers indented underneath)
code C62509
Contributing_Source CTRP
Legacy_Concept_Name IMP321
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C62509

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