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Version: 16.10e (Release date: 2016-10-31)
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Barasertib (Code C62502)

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Terms & Properties

Preferred Name: Barasertib

Definition: An orally bioavailable, small-molecule, dihydrogen phosphate prodrug of the pyrazoloquinazoline Aurora kinase inhibitor AZD1152-hydroxyquinazoline pyrazol anilide (AZD1152-HQPA) with potential antineoplastic activity. Upon administration and rapid conversion from the prodrug form in plasma, AZD1152-HQPA specifically binds to and inhibits Aurora kinase B, which results in the disruption of spindle checkpoint functions and chromosome alignment and, so, the disruption of chromosome segregation and cytokinesis. Consequently, cell division and cell proliferation are inhibited and apoptosis is induced in Aurora kinase B-overexpressing tumor cells. Aurora kinase B, a serine/threonine protein kinase that functions in the attachment of the mitotic spindle to the centromere, is overexpressed in a wide variety of cancer cell types.

Display Name: Barasertib

Label: Barasertib

NCI Thesaurus Code: C62502 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1831923  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
1h-pyrazole-3-acetamide, 5-((7-(3-(ethyl(2-(phosphonooxy)ethyl)amino)propoxy)-4-quinazolinyl)amino)-n-(3-fluorophenyl)-
Aurora Kinase Inhibitor AZD1152
AZD-1152
AZD1152
Barasertib
BARASERTIB

External Source Codes: 
CAS Registry Number 722543-31-9 (see NLM ChemIDplus info)
FDA UNII Code 16XC2U7W8N
PDQ Closed Trial Search ID 496937
PDQ Open Trial Search ID 496937 (check for NCI PDQ open clinical trial info)
UMLS CUI C1831923

Other Properties:
Name Value (qualifiers indented underneath)
Chemical_Formula C26H31FN7O6P
code C62502
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name AZD1152
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C62502

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