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Version: 17.10e (Release date: 2017-10-30)
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Eltrombopag Olamine (Code C62501)

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Terms & Properties

Preferred Name: Eltrombopag Olamine

Definition: The orally active ethanolamine salt of eltrombopag, a small-molecule, nonpeptide thrombopoietin receptor agonist with megakaryopoiesis-stimulating activity. Eltrombopag binds to and stimulates the transmembrane domain of the platelet thrombopoietin receptor (TPO-R or CD110), a member of the hematopoietin receptor superfamily. Activation of TPO-R leads to the proliferation and differentiation of cells in the megakaryocytic lineage and an increase in platelet production.

NCI-GLOSS Definition: A drug used to treat chronic immune thrombocytopenic purpura (a condition in which platelets are destroyed by the immune system). It causes more platelets to be made in the bone marrow. It is also being studied in the treatment of low platelet counts caused by chemotherapy. It is a type of thrombopoietin receptor agonist.

Display Name: Eltrombopag Olamine

Label: Eltrombopag Olamine

NCI Thesaurus Code: C62501 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1880492  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Eltrombopag Olamine
eltrombopag olamine

External Source Codes: 
CAS Registry Number 496775-62-3 (see NLM ChemIDplus info)
FDA UNII Code 4U07F515LG
PDQ Closed Trial Search ID 420847
PDQ Open Trial Search ID 420847 (check for NCI PDQ open clinical trial info)
UMLS CUI C1880492

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Chronic Idiopathic Thrombocytopenic Purpura
Chemical_Formula C25H22N4O4.2C2H7NO
code C62501
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Eltrombopag
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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