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Version: 17.08d (Release date: 2017-08-28)
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Mannitol (Code C625)

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Terms & Properties

Preferred Name: Mannitol

Definition: A naturally occurring alcohol found in fruits and vegetables and used as an osmotic diuretic. Mannitol is freely filtered by the glomerulus and poorly reabsorbed from the renal tubule, thereby causing an increase in osmolarity of the glomerular filtrate. An increase in osmolarity limits tubular reabsorption of water and inhibits the renal tubular reabsorption of sodium, chloride, and other solutes, thereby promoting diuresis. In addition, mannitol elevates blood plasma osmolarity, resulting in enhanced flow of water from tissues into interstitial fluid and plasma.

NCI-GLOSS Definition: A drug used to decrease swelling of the brain and to treat kidney failure. Mannitol can also be used to open the blood-brain barrier, which allows anticancer medicines to enter the brain and treat brain tumors.

Display Name: Mannitol

Label: Mannitol

NCI Thesaurus Code: C625 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0024730  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Mannitol, D-

External Source Codes: 
CAS Registry Number 69-65-8 (see NLM ChemIDplus info)
ChEBI ID CHEBI:16899 (see ChEBI info)
NSC Code 407017 (see NCI DTP info)
PDQ Closed Trial Search ID 39493
PDQ Open Trial Search ID 39493 (check for NCI PDQ open clinical trial info)
UMLS CUI C0024730

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C6H14O6
code C625
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Mannitol
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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