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Version: 17.06d (Release date: 2017-06-26)
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Denenicokin (Code C62492)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Denenicokin

Definition: A recombinant peptide similar to or identical to endogenous human cytokine interleukin-21 (IL-21) with potential antineoplastic activity. Denenicokin binds to and activates IL-21 receptors, expressed on T-cells, B-cells, dendritic cells (DC), and natural killer (NK) cells, modulating the proliferation and/or differentiation of T and B cells, promoting T cell survival, and increasing the cytolytic activity of cytotoxic T lymphocytes (CTLs) and NK cells.

Display Name: Denenicokin

Label: Denenicokin

NCI Thesaurus Code: C62492 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1831593  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Denenicokin
DENENICOKIN
IL-21
L-methionyl(Human Interleukin-21)
Recombinant Human Interleukin-21
rhIL-21
rIL-21

External Source Codes: 
CAS Registry Number 716840-32-3 (see NLM ChemIDplus info)
FDA UNII Code A4LY1V9F0H
PDQ Closed Trial Search ID 409696
PDQ Open Trial Search ID 409696 (check for NCI PDQ open clinical trial info)
UMLS CUI C1831593

Other Properties:
     Name Value (qualifiers indented underneath)
code C62492
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Recombinant_Human_Interleukin-21
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C62492

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