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Version: 16.11d (Release date: 2016-11-28)
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Indium In 111-CMD-193 (Code C62481)

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Terms & Properties

Preferred Name: Indium In 111-CMD-193

Definition: A radiolabeled antibody-targeted antineoplastic antibiotic consisting of the enediyne antibiotic calicheamicin conjugated with anti-Lewis Y antibody and labeled with indium In 111. In 111 CMD-193 binds to Lewis Y antigen-expressing tumor cells via its antibody moiety and is internalized; subsequently, the calicheamicin moiety binds to the minor groove of tumor cell DNA, causing double-strand DNA breaks, the inhibition of DNA synthesis, and apoptosis. The indium In 111 radiolabel allows the detection of CMD-193 distribution and tumor localization using gamma scintigraphy.

Label: Indium In 111-CMD-193

NCI Thesaurus Code: C62481 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1831887  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Indium In 111-CMD-193
In 111 CMD-193

External Source Codes: 
PDQ Closed Trial Search ID 489294
PDQ Open Trial Search ID 489294 (check for NCI PDQ open clinical trial info)
UMLS CUI C1831887

Other Properties:
Name Value (qualifiers indented underneath)
code C62481
Legacy_Concept_Name In_111_CMD-193
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Indicator, Reagent, or Diagnostic Aid

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C62481

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