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Version: 17.06d (Release date: 2017-06-26)
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Immunotoxin CMD-193 (Code C62480)

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Terms & Properties

Preferred Name: Immunotoxin CMD-193

Definition: A humanized immunotoxin directed against the Lewis Y antigen conjugated with calicheamicin, a hydrophobic enediyne antibiotic, with potential antineoplastic activity. CMD193 binds to the Lewis Y antigen, a tetrasaccharide expressed on the cell surfaces of many tumor cell types. Upon binding, CMD-193 is internalized, thereby delivering the attached calicheamicin to Lewis Y antigen-expressing tumor cells. Calicheamicin binds non-covalently to the minor groove of DNA and prompts conformational changes and DNA oxidation, thereby inhibiting DNA synthesis and inducing apoptosis.

Label: Immunotoxin CMD-193

NCI Thesaurus Code: C62480 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1879965  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Immunotoxin CMD-193

External Source Codes: 
PDQ Closed Trial Search ID 489295
PDQ Open Trial Search ID 489295 (check for NCI PDQ open clinical trial info)
UMLS CUI C1879965

Other Properties:
     Name Value (qualifiers indented underneath)
code C62480
Legacy_Concept_Name CMD-193
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C62480

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