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Version: 17.06d (Release date: 2017-06-26)
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Folate-FITC (Code C62479)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Folate-FITC

Definition: A conjugate consisting of fluorescein isothiocyanate (FITC) conjugated with folate with potential antineoplastic activity. Folate-FITC binds to folate receptors, which are overexpressed on the surfaces of many cancer cells including kidney and ovarian cancer cells. Once bound to the cancer cell through the folate moiety of the conjugate, circulating anti-fluorescein antibodies may recognize and bind to the FITC moiety, resulting in antibody-dependent cellular cytotoxicity.

Display Name: Folate-FITC

Label: Folate-FITC

NCI Thesaurus Code: C62479 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1831885  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
EC-17
EC17
Folate-FITC
Folate Fluorescein Isothiocyanate Conjugate
L-glutamine, N2-(4-(((2-amino-3,4-dihydro-4-oxo-6-pteridinyl)methyl)amino)benzoyl)-n-(2-((((3',6'-dihydroxy-3-oxospiro(isobenzofuran-1(3h),9'-(9h)xanthen)-5-yl)amino)thioxomethyl)amino)ethyl)-

External Source Codes: 
FDA UNII Code V7YQ6134AE
PDQ Closed Trial Search ID 489286
PDQ Open Trial Search ID 489286 (check for NCI PDQ open clinical trial info)
UMLS CUI C1831885

Other Properties:
     Name Value (qualifiers indented underneath)
code C62479
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name EC17
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C62479

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