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Version: 17.06d (Release date: 2017-06-26)
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Urelumab (Code C62449)

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Terms & Properties

Preferred Name: Urelumab

Definition: A fully human agonistic monoclonal antibody targeting the CD137 receptor with potential immunostimulatory and antineoplastic activities. Anti-CD137 monoclonal antibody specifically binds to and activates CD137-expressing immune cells, stimulating an immune response, in particular a cytotoxic T cell response, against tumor cells. CD137 is a member of the tumor necrosis factor (TNF)/nerve growth factor (NGF) family of receptors and is expressed by activated T- and B-lymphocytes and monocytes; its ligand has been found to play an important role in the regulation of immune responses.

Display Name: Urelumab

Label: Urelumab

NCI Thesaurus Code: C62449 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1831875  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Anti-4-1BB Monoclonal Antibody
Anti-CD137 Monoclonal Antibody
BMS-663513
Immunoglobulin G4, Anti-(Human Receptor 4-1BB) (Human Gamma-Chain), Disulfide with Human Kappa-Chain, Dimer
Urelumab
URELUMAB

External Source Codes: 
CAS Registry Number 934823-49-1 (see NLM ChemIDplus info)
FDA UNII Code 230902QLLC
PDQ Closed Trial Search ID 489120
PDQ Open Trial Search ID 489120 (check for NCI PDQ open clinical trial info)
UMLS CUI C1831875

Other Properties:
     Name Value (qualifiers indented underneath)
code C62449
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Anti-CD137_Monoclonal_Antibody
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Immunologic Factor

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C62449

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