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Version: 17.06d (Release date: 2017-06-26)
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Catumaxomab (Code C62445)

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Terms & Properties

Preferred Name: Catumaxomab

Definition: A trifunctional bispecific monoclonal antibody with potential antineoplastic activity. Catumaxomab has two antigen-recognition sites: one for human CD3, a T cell surface antigen; and one for human epithelial cell adhesion molecule (EpCAM), a cell surface antigen expressed by a variety of epithelial tumor cells. In addition, the modified Fc portion of this antibody binds Fc receptors on antigen presenting cells (APCs) such as macrophages and dendritic cells (DCs). Catumaxomab brings T cells, EpCAM-expressing epithelial tumor cells and APCs together into tricellular complexes, which may result in a potent cytotoxic T-lymphocyte (CTL) response against EpCAM-expressing epithelial tumor cells. Fc-mediated binding of APCs in the tricellular complex potentiates EpCAM antigen presentation to T cells and the activation of anti-tumor cytotoxic T cell functions.

Display Name: Catumaxomab

Label: Catumaxomab

NCI Thesaurus Code: C62445 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1831854  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)

External Source Codes: 
PDQ Closed Trial Search ID 487002
PDQ Open Trial Search ID 487002 (check for NCI PDQ open clinical trial info)
PubMedID Primary Reference 17622246 (see PubMed Primary Reference info)
UMLS CUI C1831854

Other Properties:
     Name Value (qualifiers indented underneath)
code C62445
Contributing_Source CTRP
Legacy_Concept_Name Catumaxomab
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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