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Version: 17.06d (Release date: 2017-06-26)
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Tivantinib (Code C62437)

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Terms & Properties

Preferred Name: Tivantinib

Definition: An orally bioavailable small molecule inhibitor of c-Met with potential antineoplastic activity. c-Met inhibitor ARQ 197 binds to the c-Met protein and disrupts c-Met signal transduction pathways, which may induce cell death in tumor cells overexpressing c-Met protein or expressing constitutively activated c-Met protein. c-Met protein, the product of the proto-oncogene c-Met, is a receptor tyrosine kinase also known as hepatocyte growth factor receptor (HGFR); this protein is overexpressed or mutated in many tumor cell types and plays key roles in tumor cell proliferation, survival, invasion, and metastasis, and tumor angiogenesis.

Display Name: Tivantinib

Label: Tivantinib

NCI Thesaurus Code: C62437 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1831873  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
(3R,4R)-3-(5,6-Dihydro-4H-pyrrolo(3,2,1-ij)quinolin-1-yl)-4-(1H-indol-3-yl)pyrrolidine-2,5-dione
ARQ-197
ARQ 197
c-Met Inhibitor ARQ 197
Tivantinib
TIVANTINIB

External Source Codes: 
CAS Registry Number 905854-02-6 (see NLM ChemIDplus info)
FDA UNII Code PJ4H73IL17
PDQ Closed Trial Search ID 488957
PDQ Open Trial Search ID 488957 (check for NCI PDQ open clinical trial info)
UMLS CUI C1831873

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C23H19N3O2
code C62437
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name ARQ_197
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C62437

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