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Version: 17.06d (Release date: 2017-06-26)
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Tivantinib (Code C62437)

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Terms & Properties

Preferred Name: Tivantinib

Definition: An orally bioavailable small molecule inhibitor of c-Met with potential antineoplastic activity. c-Met inhibitor ARQ 197 binds to the c-Met protein and disrupts c-Met signal transduction pathways, which may induce cell death in tumor cells overexpressing c-Met protein or expressing constitutively activated c-Met protein. c-Met protein, the product of the proto-oncogene c-Met, is a receptor tyrosine kinase also known as hepatocyte growth factor receptor (HGFR); this protein is overexpressed or mutated in many tumor cell types and plays key roles in tumor cell proliferation, survival, invasion, and metastasis, and tumor angiogenesis.

Display Name: Tivantinib

Label: Tivantinib

NCI Thesaurus Code: C62437 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1831873  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
ARQ 197
c-Met Inhibitor ARQ 197

External Source Codes: 
CAS Registry Number 905854-02-6 (see NLM ChemIDplus info)
PDQ Closed Trial Search ID 488957
PDQ Open Trial Search ID 488957 (check for NCI PDQ open clinical trial info)
UMLS CUI C1831873

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C23H19N3O2
code C62437
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name ARQ_197
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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