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Version: 17.06d (Release date: 2017-06-26)
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Dovitinib Lactate (Code C62435)

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Terms & Properties

Preferred Name: Dovitinib Lactate

Definition: The orally bioavailable lactate salt of a benzimidazole-quinolinone compound with potential antineoplastic activity. Dovitinib strongly binds to fibroblast growth factor receptor 3 (FGFR3) and inhibits its phosphorylation, which may result in the inhibition of tumor cell proliferation and the induction of tumor cell death. In addition, this agent may inhibit other members of the RTK superfamily, including the vascular endothelial growth factor receptor; fibroblast growth factor receptor 1; platelet-derived growth factor receptor type 3; FMS-like tyrosine kinase 3; stem cell factor receptor (c-KIT); and colony-stimulating factor receptor 1; this may result in an additional reduction in cellular proliferation and angiogenesis, and the induction of tumor cell apoptosis. The activation of FGFR3 is associated with cell proliferation and survival in certain cancer cell types.

Display Name: Dovitinib Lactate

Label: Dovitinib Lactate

NCI Thesaurus Code: C62435 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1568328  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
4-Amino-5-fluoro-3-(6-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl)quinolin-2(1H)-one mono 2-hydroxypropanoate Hydrate
CHIR-258
Dovitinib Lactate
DOVITINIB LACTATE
RTK Inhibitor TKI258
TKI258

External Source Codes: 
CAS Registry Number 915769-50-5 (see NLM ChemIDplus info)
FDA UNII Code 69VKY8P7EA
PDQ Closed Trial Search ID 488976
PDQ Open Trial Search ID 488976 (check for NCI PDQ open clinical trial info)
UMLS CUI C1568328

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C21H21FN6O.C3H6O3.H2O
code C62435
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name CHIR-258
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C62435

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