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Version: 17.06d (Release date: 2017-06-26)
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Amphotericin B Deoxycholate (Code C62201)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Amphotericin B Deoxycholate

Definition: The deoxycholate salt of amphotericin B, a polyene antifungal antibiotic produced by Streptomyces nodosus, with antifungal activity. Amphotericin B binds to ergosterol, an essential component of the fungal cell membrane. This results in depolarization of the cell membrane, alterations in cell membrane permeability, leakage of important intracellular components, and cell rupture. This agent may also induce oxidative damage in fungal cells and has been reported to stimulate host immune cells.

Label: Amphotericin B Deoxycholate

NCI Thesaurus Code: C62201 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0051761  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Amphotericin B-deoxycholate
Amphotericin B Deoxycholate
Fungizone

External Source Codes: 
CAS Registry Number 58501-21-6 (see NLM ChemIDplus info)
PDQ Closed Trial Search ID 39143
PDQ Open Trial Search ID 39143 (check for NCI PDQ open clinical trial info)
UMLS CUI C0051761

Other Properties:
     Name Value (qualifiers indented underneath)
code C62201
Legacy_Concept_Name Amphotericin_B_Deoxycholate
Semantic_Type Antibiotic
Semantic_Type Organic Chemical

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C62201

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