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Version: 16.10e (Release date: 2016-10-31)
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Dacetuzumab (Code C62179)

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Terms & Properties

Preferred Name: Dacetuzumab

Definition: A humanized monoclonal antibody directed against the CD40 receptor with potential antineoplastic activity. Dacetuzumab specifically binds to and inhibits the CD40 receptor, thereby inducing apoptosis and inhibiting cellular proliferation via antibody-dependent cellular cytotoxicity (ADCC) in cells that overexpress this receptor. The CD40 receptor, a member of the tumor necrosis factor (TNF) receptor super-family, is highly expressed on most B lineage hematologic malignancies including multiple myeloma, non-Hodgkin's lymphoma, chronic lymphocytic leukemia, Hodgkin's disease and acute lymphoblastic leukemia.

NCI-GLOSS Definition: A monoclonal antibody that binds to cells that have the CD40 antigen on their surface, including cells from multiple myeloma, non-Hodgkin lymphoma, and chronic lymphocytic leukemia. SGN-40 is being studied in the treatment of cancer. It is a type of monoclonal antibody.

Display Name: Dacetuzumab

Label: Dacetuzumab

NCI Thesaurus Code: C62179 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2742509  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Anti-huCD40 mAb
Dacetuzumab
DACETUZUMAB
huS2C6
Monoclonal Antibody SGN-40
SGN-40

External Source Codes: 
CAS Registry Number 880486-59-9 (see NLM ChemIDplus info)
FDA UNII Code UT59FF4T5X
PDQ Closed Trial Search ID 365545
PDQ Open Trial Search ID 365545 (check for NCI PDQ open clinical trial info)
UMLS CUI C2742509

Other Properties:
Name Value (qualifiers indented underneath)
code C62179
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name SGN-40
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Immunologic Factor

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C62179

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