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Version: 17.08d (Release date: 2017-08-28)
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Dacetuzumab (Code C62179)

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Terms & Properties

Preferred Name: Dacetuzumab

Definition: A humanized monoclonal antibody directed against the CD40 receptor with potential antineoplastic activity. Dacetuzumab specifically binds to and inhibits the CD40 receptor, thereby inducing apoptosis and inhibiting cellular proliferation via antibody-dependent cellular cytotoxicity (ADCC) in cells that overexpress this receptor. The CD40 receptor, a member of the tumor necrosis factor (TNF) receptor super-family, is highly expressed on most B lineage hematologic malignancies including multiple myeloma, non-Hodgkin's lymphoma, chronic lymphocytic leukemia, Hodgkin's disease and acute lymphoblastic leukemia.

NCI-GLOSS Definition: A monoclonal antibody that binds to cells that have the CD40 antigen on their surface, including cells from multiple myeloma, non-Hodgkin lymphoma, and chronic lymphocytic leukemia. SGN-40 is being studied in the treatment of cancer. It is a type of monoclonal antibody.

Display Name: Dacetuzumab

Label: Dacetuzumab

NCI Thesaurus Code: C62179 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2742509  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Anti-huCD40 mAb
Monoclonal Antibody SGN-40

External Source Codes: 
CAS Registry Number 880486-59-9 (see NLM ChemIDplus info)
PDQ Closed Trial Search ID 365545
PDQ Open Trial Search ID 365545 (check for NCI PDQ open clinical trial info)
UMLS CUI C2742509

Other Properties:
     Name Value (qualifiers indented underneath)
code C62179
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name SGN-40
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Immunologic Factor

Additional Concept Data: 
Defined Fully by Roles: No  


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