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Version: 17.06d (Release date: 2017-06-26)
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L-Gossypol (Code C62178)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: L-Gossypol

Definition: The levo-enantiomer of an orally bioavailable polyphenolic aldehyde, derived primarily from unrefined cottonseed oil, with potential antineoplastic activity. Mimicking the inhibitory BH3 (Bcl-2 homology 3) domain of endogenous antagonists of Bcl-2, L-gossypol binds to and inhibits various anti-apoptotic Bcl-2 proteins, which may result in the inhibition of tumor cell proliferation and the induction of tumor cell apoptosis. This agent has greater affinity for Bcl-2 proteins than racemic gossypol.

Label: L-Gossypol

NCI Thesaurus Code: C62178 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1831823  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
L-Gossypol

External Source Codes: 
CAS Registry Number 90141-22-3 (see NLM ChemIDplus info)
PDQ Closed Trial Search ID 570759
PDQ Open Trial Search ID 570759 (check for NCI PDQ open clinical trial info)
UMLS CUI C1831823

Other Properties:
     Name Value (qualifiers indented underneath)
code C62178
Legacy_Concept_Name L-Gossypol
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C62178

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