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Version: 17.06d (Release date: 2017-06-26)
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Lovastatin (Code C620)

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Terms & Properties

Preferred Name: Lovastatin

Definition: A lactone metabolite isolated from the fungus Aspergillus terreus with cholesterol-lowering and potential antineoplastic activities. Lovastatin is hydrolyzed to the active beta-hydroxyacid form, which competitively inhibits 3-hydroxyl-3-methylgutarylcoenzyme A (HMG-CoA) reductase, an enzyme involved in cholesterol biosynthesis. In addition, this agent may induce tumor cell apoptosis and inhibit tumor cell invasiveness, possibly by inhibiting protein farnesylation and protein geranylgeranylation, and may arrest cells in the G1 phase of the cell cycle. The latter effect sensitizes tumor cells to the cytotoxic effects of ionizing radiation.

NCI-GLOSS Definition: A drug used to lower the amount of cholesterol in the blood. It is also being studied in the prevention and treatment of some types of cancer. Lovastatin is a type of HMG-CoA reductase inhibitor (statin).

Display Name: Lovastatin

Label: Lovastatin

NCI Thesaurus Code: C620 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0024027  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
(2S)-2-Methylbutanoic Acid, (1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-Hexahydro-3,7-dimethyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl Ester
Lovastatin
LOVASTATIN
lovastatin
Lovastatin Sodium
Mevacor
Mevinolin
Monacolin K

External Source Codes: 
CAS Registry Number 75330-75-5 (see NLM ChemIDplus info)
FDA UNII Code 9LHU78OQFD
ChEBI ID CHEBI:40303 (see ChEBI info)
NSC Code 633781 (see NCI DTP info)
PDQ Closed Trial Search ID 41658
PDQ Open Trial Search ID 41658 (check for NCI PDQ open clinical trial info)
UMLS CUI C0024027

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Atherosclerosis; Coronary heart disease, prevention; Hypercholesterolemia
Chemical_Formula C24H36O5
code C620
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Lovastatin
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C620

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