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Version: 17.06d (Release date: 2017-06-26)
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Trientine Hydrochloride (Code C61987)

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Terms & Properties

Preferred Name: Trientine Hydrochloride

Definition: The hydrochloride salt form of a metal chelating agent with potential anti-angiogenic activity. Trientine chelates excess copper (Cu) ions in the body; the excess copper is subsequently removed from the body through the kidneys. As Cu is an essential cofactor for cuproenzymes, such as superoxide dismutase 1 (SOD1), depletion of copper may inhibit the activation of signal transduction pathways required for cellular proliferation and angiogenesis. In addition, trientine may inhibit copper-induced secretion of interleukin-8 (IL-8).

Display Name: Trientine Hydrochloride

Label: Trientine Hydrochloride

NCI Thesaurus Code: C61987 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0770325  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
N,N-bis (2-aminoethyl)-1,2-ethanediamine Dihydrochloride
Syprine
Trientine Hydrochloride
TRIENTINE HYDROCHLORIDE

External Source Codes: 
CAS Registry Number 38260-01-4 (see NLM ChemIDplus info)
FDA UNII Code HC3NX54582
PDQ Closed Trial Search ID 683662
PDQ Open Trial Search ID 683662 (check for NCI PDQ open clinical trial info)
UMLS CUI C0770325

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C6H18N4.2HCl
code C61987
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Trientine_Hydrochloride
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C61987

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