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Version: 17.06d (Release date: 2017-06-26)
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Tiotropium Bromide Monohydrate (Code C61974)

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Terms & Properties

Preferred Name: Tiotropium Bromide Monohydrate

Definition: The monohydrate bromide salt form of tiotropium, a quaternary ammonium derivative of atropine and a long-acting muscarinic receptor antagonist, with bronchodilating activity. Upon inhalation, tiotropium binds to and blocks mainly muscarinic M3 receptors located on smooth muscle cells, thereby preventing smooth muscle contraction.

Label: Tiotropium Bromide Monohydrate

NCI Thesaurus Code: C61974 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0905678  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
1,4-Dihydro-3,5-Diiodo-1-Methyl-4-Oxopyridine-2,6-Dicarboxylic Acid
6Beta,7Beta-Epoxy-3Beta-Hydroxy-8-Methyl-1Alpha-H,5Alpha-H-Tropanium Bromide, Di-2-Thienylglycolate Monohydrate
Spiriva
TIOTROPIUM BROMIDE MONOHYDRATE
Tiotropium Bromide Monohydrate

External Source Codes: 
CAS Registry Number 411207-31-3 (see NLM ChemIDplus info)
FDA UNII Code L64SXO195N
PDQ Closed Trial Search ID 682857
PDQ Open Trial Search ID 682857 (check for NCI PDQ open clinical trial info)
UMLS CUI C0905678

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C19H22NO4S2.Br.H2O
code C61974
Contributing_Source FDA
Legacy_Concept_Name Tiotropium_Bromide_Monohydrate
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C61974

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