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Version: 17.12d (Release date: 2017-12-26)
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Lorazepam (Code C619)

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Terms & Properties

Preferred Name: Lorazepam

Definition: A benzodiazepine with anxiolytic, anti-anxiety, anticonvulsant, anti-emetic and sedative properties. Lorazepam enhances the effect of the inhibitory neurotransmitter gamma-aminobutyric acid on the GABA receptors by binding to a site that is distinct from the GABA binding site in the central nervous system. This leads to an increase in chloride channel opening events, a facilitation of chloride ion conductance, membrane hyperpolarization, and eventually inhibition of the transmission of nerve signals, thereby decreasing nervous excitation.

NCI-GLOSS Definition: A drug that is used to treat anxiety and certain seizure disorders (such as epilepsy), and to prevent nausea and vomiting caused by chemotherapy. It belongs to the families of drugs called antiemetics and benzodiazepines.

Display Name: Lorazepam

Label: Lorazepam

NCI Thesaurus Code: C619 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0699194  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
7-Chloro-5-(2-chlorophenyl)-1, 3-Dihydro-3-Hydroxy-1,4- Benzodiazepin-2-one

External Source Codes: 
CAS Registry Number 846-49-1 (see NLM ChemIDplus info)
NSC Code 289758 (see NCI DTP info)
PDQ Closed Trial Search ID 39757
PDQ Open Trial Search ID 39757 (check for NCI PDQ open clinical trial info)
UMLS CUI C0699194

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C15H10Cl2N2O2
code C619
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Lorazepam
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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