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Version: 17.06d (Release date: 2017-06-26)
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Pantoprazole Sodium (Code C61877)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Pantoprazole Sodium

Definition: The sodium salt form of a substituted benzimidazole with proton pump inhibitor activity. Pantoprazole is a lipophilic, weak base that crosses the parietal cell membrane and enters the acidic parietal cell canaliculus where it becomes protonated, producing the active metabolite sulfenamide, which forms an irreversible covalent bond with two sites of the H+/K+-ATPase enzyme located on the gastric parietal cell, thereby inhibiting both basal and stimulated gastric acid production.

Label: Pantoprazole Sodium

NCI Thesaurus Code: C61877 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0795650  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Pantoprazole Sodium
PANTOPRAZOLE SODIUM
Protonix

External Source Codes: 
CAS Registry Number 164579-32-2 (see NLM ChemIDplus info)
FDA UNII Code 6871619Q5X
ChEBI ID CHEBI:50270 (see ChEBI info)
UMLS CUI C0795650

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Gastroesophageal Reflux Disease
Chemical_Formula 2C16H14F2N3O4S.2Na.3H2O
code C61877
Contributing_Source FDA
Legacy_Concept_Name Pantoprazole_Sodium
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C61877

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