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Version: 16.11d (Release date: 2016-11-28)
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Metoprolol (Code C61845)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Metoprolol

Definition: A cardioselective competitive beta-1 adrenergic receptor antagonist with antihypertensive properties and devoid of intrinsic sympathomimetic activity. Metoprolol antagonizes beta 1-adrenergic receptors in the myocardium, thereby reducing the rate and force of myocardial contraction leading to a reduction in cardiac output. This agent may also reduce the secretion of renin with subsequent reduction in levels of angiotensin II thereby preventing vasoconstriction and aldosterone secretion.

Display Name: Metoprolol

Label: Metoprolol

NCI Thesaurus Code: C61845 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0025859  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Metoprolol
METOPROLOL

External Source Codes: 
CAS Registry Number 51384-51-1 (see NLM ChemIDplus info)
FDA UNII Code GEB06NHM23
ChEBI ID CHEBI:6904 (see ChEBI info)
PDQ Closed Trial Search ID 694582
PDQ Open Trial Search ID 694582 (check for NCI PDQ open clinical trial info)
UMLS CUI C0025859

Other Properties:
Name Value (qualifiers indented underneath)
Chemical_Formula C15H25NO3
code C61845
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Metoprolol
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C61845

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