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Version: 17.06d (Release date: 2017-06-26)
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Mefloquine (Code C61827)

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Terms & Properties

Preferred Name: Mefloquine

Definition: A quinolinemethanol derivative with antimalarial, anti-inflammatory, and potential chemosensitization and radiosensitization activities. Although the exact mechanism remains to be elucidated, mefloquine, a weak base, preferentially accumulates in lysosomes and disrupts lysosomal function and integrity, thereby leading to host cell death. Similar to chloroquine, the chemosensitizing and radiosensitizing activities of this agent may be related to its inhibition of autophagocytosis, a cellular mechanism involving lysosomal degradation that minimizes the production of reactive oxygen species (ROS) related to tumor reoxygenation and tumor exposure to chemotherapeutic agents and radiation. Compared to chloroquine, mefloquine has better blood-brain-barrier (BBB) penetration.

Display Name: Mefloquine

Label: Mefloquine

NCI Thesaurus Code: C61827 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0025153  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)

External Source Codes: 
CAS Registry Number 53230-10-7 (see NLM ChemIDplus info)
FDA UNII Code TML814419R
ChEBI ID CHEBI:63609 (see ChEBI info)
PDQ Closed Trial Search ID 711805
PDQ Open Trial Search ID 711805 (check for NCI PDQ open clinical trial info)
UMLS CUI C0025153

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C17H16F6N2O
code C61827
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Mefloquine
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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