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Version: 17.10e (Release date: 2017-10-30)
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Ethambutol (Code C61755)

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Terms & Properties

Preferred Name: Ethambutol

Definition: An antibiotic with bacteriostatic, antimicrobial and antitubercular properties. Ethambutol interferes with the biosynthesis of arabinogalactan, a major polysaccharide of the mycobacterial cell wall. It inhibits the polymerization of cell wall arabinan of arabinogalactan and lipoarabinomannan by blocking arabinosyl transferases and induces the accumulation of D-arabinofuranosyl-P-decaprenol, an intermediate in arabinan biosynthesis. This results in halting bacterial growth.

Label: Ethambutol

NCI Thesaurus Code: C61755 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0014964  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)

External Source Codes: 
CAS Registry Number 74-55-5 (see NLM ChemIDplus info)
FDA UNII Code 8G167061QZ
ChEBI ID CHEBI:4877 (see ChEBI info)
UMLS CUI C0014964

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C10H24N2O2
code C61755
Contributing_Source FDA
Legacy_Concept_Name Ethambutol
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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