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Version: 17.08d (Release date: 2017-08-28)
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Ertapenem Sodium (Code C61753)

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Terms & Properties

Preferred Name: Ertapenem Sodium

Definition: The sodium salt of ertapenem, a 1-beta-methyl carbapenem and a broad-spectrum beta-lactam antibiotic with bactericidal activity. Ertapenem binds to penicillin binding proteins (PBPs) located on the bacterial cell wall, in particular PBPs 2 and 3, thereby inhibiting the final transpeptidation step in the synthesis of peptidoglycan, an essential component of the bacterial cell wall. Inhibition of peptidoglycan synthesis results in weakening and lysis of the cell wall and cell death. In vitro, this agent has shown activity against Gram-positive and Gram-negative aerobic and anaerobic bacteria. Erapenem is resistant to hydrolysis by a variety of beta-lactamases, including penicillinases, cephalosporinases and extended-spectrum beta-lactamases.

Label: Ertapenem Sodium

NCI Thesaurus Code: C61753 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1170745  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Ertapenem Sodium

External Source Codes: 
CAS Registry Number 153832-38-3 (see NLM ChemIDplus info)
FDA UNII Code 2T90KE67L0
ChEBI ID CHEBI:60070 (see ChEBI info)
PDQ Closed Trial Search ID 573502
PDQ Open Trial Search ID 573502 (check for NCI PDQ open clinical trial info)
UMLS CUI C1170745

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C22H23N3O7S."H".Na
code C61753
Contributing_Source FDA
Legacy_Concept_Name Ertapenem_Sodium
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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