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Version: 17.06d (Release date: 2017-06-26)
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Enclomiphene Citrate (Code C61745)

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Terms & Properties

Preferred Name: Enclomiphene Citrate

Definition: The orally bioavailable citrate salt of enclomiphene, the trans-isomer of the nonsteroidal triphenylethylene compound clomiphene, with tissue-selective estrogenic and antiestrogenic activities. As a selective estrogen receptor modulator (SERM), enclomiphene binds to hypothalamic estrogen receptors, blocking the negative feedback of endogenous estrogens and stimulating the release of gonadotropin-releasing hormone (GnRH) from the hypothalamus; released GnRH subsequently stimulates the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the anterior pituitary, resulting in ovulation. In addition, this agent may bind to estrogen receptors on breast cancer cells, resulting in the inhibition of estrogen-stimulated proliferation in susceptible cell populations.

Label: Enclomiphene Citrate

NCI Thesaurus Code: C61745 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0086214  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Enclomiphene Citrate

External Source Codes: 
CAS Registry Number 7599-79-3 (see NLM ChemIDplus info)
FDA UNII Code J303A6U9Y6
PDQ Closed Trial Search ID 39307
PDQ Open Trial Search ID 39307 (check for NCI PDQ open clinical trial info)
UMLS CUI C0086214

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C26H28ClNO.C6H8O7
code C61745
Contributing_Source FDA
Legacy_Concept_Name Enclomiphene_Citrate
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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