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Version: 17.06d (Release date: 2017-06-26)
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Lomustine (Code C617)

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Terms & Properties

Preferred Name: Lomustine

Definition: A nitrosourea with antineoplastic activity. Lomustine alkylates and crosslinks DNA, thereby inhibiting DNA and RNA synthesis. This agent also carbamoylates DNA and proteins, resulting in inhibition of DNA and RNA synthesis and disruption of RNA processing. Lomustine is lipophilic and crosses the blood-brain barrier. (NCI04)

NCI-GLOSS Definition: An anticancer drug that belongs to the family of drugs called alkylating agents.

Display Name: Lomustine

Label: Lomustine

NCI Thesaurus Code: C617 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0023972  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
1-(2-Chloroethyl)-3-cyclohexyl-1-nitrosourea
1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea
1-Nitrosourea, 1-(2-chloroethyl)-3-cyclohexyl-
Belustin
Belustine
CCNU
Cecenu
CeeNU
Chloroethylcyclo- hexylnitrosourea
Chloroethylcyclohexylnitrosourea
Citostal
Lomeblastin
Lomustine
LOMUSTINE
lomustine
Lomustinum
Lucostin
Lucostine
N-(2-chloroethyl)-N'-cyclohexyl-N-nitrosourea
N-(2-Chloroethyl)-N'-cyclohexyl-N-nitrosourea
Prava
RB-1509
WR-139017

External Source Codes: 
CAS Registry Number 13010-47-4 (see NLM ChemIDplus info)
FDA UNII Code 7BRF0Z81KG
NSC Code 79037 (see NCI DTP info)
PDQ Closed Trial Search ID 43065
PDQ Open Trial Search ID 43065 (check for NCI PDQ open clinical trial info)
UMLS CUI C0023972

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Brain tumors; Hodgkins disease
Chemical_Formula C9H16ClN3O2
code C617
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Lomustine
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C617

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