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National Cancer Institute
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Version: 17.06d (Release date: 2017-06-26)
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Chloroquine (Code C61671)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Chloroquine

Definition: A 4-aminoquinoline with antimalarial, anti-inflammatory, and potential chemosensitization and radiosensitization activities. Although the mechanism is not well understood, chloroquine is shown to inhibit the parasitic enzyme heme polymerase that converts the toxic heme into non-toxic hemazoin, thereby resulting in the accumulation of toxic heme within the parasite. This agent may also interfere with the biosynthesis of nucleic acids. Chloroquine's potential chemosensitizing and radiosensitizing activities in cancer may be related to its inhibition of autophagy, a cellular mechanism involving lysosomal degradation that minimizes the production of reactive oxygen species (ROS) related to tumor reoxygenation and tumor exposure to chemotherapeutic agents and radiation.

Display Name: Chloroquine

Label: Chloroquine

NCI Thesaurus Code: C61671 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0008269  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)

External Source Codes: 
CAS Registry Number 54-05-7 (see NLM ChemIDplus info)
ChEBI ID CHEBI:3638 (see ChEBI info)
PDQ Closed Trial Search ID 654729
PDQ Open Trial Search ID 654729 (check for NCI PDQ open clinical trial info)
UMLS CUI C0008269

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C18H26ClN3
code C61671
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Chloroquine
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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