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Version: 16.11d (Release date: 2016-11-28)
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Alpha-Lipoic Acid (Code C61595)

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Terms & Properties

Preferred Name: Alpha-Lipoic Acid

Definition: A naturally occurring micronutrient, synthesized in small amounts by plants and animals (including humans), with antioxidant and potential chemopreventive activities. Alpha-lipoic acid acts as a free radical scavenger and assists in repairing oxidative damage and regenerates endogenous antioxidants, including vitamins C and E and glutathione. This agent also promotes glutathione synthesis. In addition, alpha-lipoic acid exerts metal chelating capacities and functions as a cofactor in various mitochondrial enzyme complexes involved in the decarboxylation of alpha-keto acids.

NCI-GLOSS Definition: A substance that is being studied for its ability to protect normal cells from the side effects of chemotherapy and prevent peripheral neuropathy (numbness, tingling, burning, and weakness in the hands or feet). Alpha-lipoic acid is made by the body and can be found in foods such as organ meats, spinach, broccoli, peas, brussel sprouts, and rice bran. It can also be made in the laboratory. Alpha-lipoic acid is a type of antioxidant and chemoprotective agent.

Display Name: Alpha-Lipoic Acid

Label: Alpha-Lipoic Acid

NCI Thesaurus Code: C61595 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0023791  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
.ALPHA.-LIPOIC ACID
5-(1,2-Dithiolan-3-yl)pentanoic Acid
6,8-Thioctic Acid
Alpha-Lipoic Acid
alpha-lipoic acid
Lipoic Acid
Thioctate
Thioctic Acid

External Source Codes: 
CAS Registry Number 1077-28-7 (see NLM ChemIDplus info)
FDA UNII Code 73Y7P0K73Y
ChEBI ID CHEBI:16494 (see ChEBI info)
PDQ Closed Trial Search ID 440740
PDQ Open Trial Search ID 440740 (check for NCI PDQ open clinical trial info)
UMLS CUI C0023791

Other Properties:
Name Value (qualifiers indented underneath)
Chemical_Formula C8H14O2S2
code C61595
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Alpha-Lipoic_Acid
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C61595

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