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Version: 16.10e (Release date: 2016-10-31)
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Hodgkin's Antigens-GM-CSF-Expressing Cell Vaccine (Code C61592)

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Terms & Properties

Preferred Name: Hodgkin's Antigens-GM-CSF-Expressing Cell Vaccine

Definition: An allogeneic vaccine consisting of Hodgkin lymphoma cells transfected with the granulocyte macrophage-colony-stimulating factor (GM-CSF) gene with potential antineoplastic activity. Upon vaccination, Hodgkin antigens-GM-CSF-expressing cell vaccine may stimulate a cytotoxic T-lymphocyte (CTL) immune response against Hodgkin lymphoma-associated antigens, which may result in the lysis of tumor cells expressing these antigens. In addition, transfected Hodgkin lymphoma cells secrete GM-CSF, which may potentiate the CTL response against Hodgkin lymphoma-associated antigens.

Display Name: Hodgkin's Antigens-GM-CSF-Expressing Cell Vaccine

Label: Hodgkin's Antigens-GM-CSF-Expressing Cell Vaccine

NCI Thesaurus Code: C61592 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1831712  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Hodgkin's Antigens-GM-CSF-Expressing Cell Vaccine
KGEL Vaccine

External Source Codes: 
PDQ Closed Trial Search ID 445421
PDQ Open Trial Search ID 445421 (check for NCI PDQ open clinical trial info)
UMLS CUI C1831712

Other Properties:
Name Value (qualifiers indented underneath)
code C61592
Contributing_Source CTRP
Legacy_Concept_Name Hodgkin_s_Antigens-GM-CSF-Expressing_Cell_Vaccine
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C61592

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