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Version: 17.06d (Release date: 2017-06-26)
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Danusertib (Code C61587)

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Terms & Properties

Preferred Name: Danusertib

Definition: A small-molecule 3-aminopyrazole derivative with potential antineoplastic activity. Danusertib binds to and inhibits the Aurora kinases, which may result in cell growth arrest and apoptosis in tumor cells in which Aurora kinases are overexpressed. This agent may preferentially bind to and inhibit Aurora B kinase. Aurora kinases, a family of serine-threonine kinases, are important regulators of cellular proliferation and division.

NCI-GLOSS Definition: A substance being studied in the treatment of chronic myelogenous leukemia. PHA-739358 may stop tumor growth by blocking certain enzymes needed for cancer cells to divide and causing them to die. It is a type of kinase inhibitor.

Display Name: Danusertib

Label: Danusertib

NCI Thesaurus Code: C61587 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2700603  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Benzamide, 4-(4-methyl-1-piperazinyl)-N-(1,4,5,6-tetrahydro-5-((2R)- methoxyphenylacetyl)pyrrolo(3,4-c)pyrazol-3-yl)-
Danusertib
DANUSERTIB
PHA-739358

External Source Codes: 
CAS Registry Number 827318-97-8 (see NLM ChemIDplus info)
FDA UNII Code M3X659D0FY
PDQ Closed Trial Search ID 489092
PDQ Open Trial Search ID 489092 (check for NCI PDQ open clinical trial info)
UMLS CUI C2700603

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C26H30N6O3
code C61587
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name PHA-739358
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C61587

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