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Version: 17.06d (Release date: 2017-06-26)
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Cantuzumab Ravtansine (Code C61576)

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Terms & Properties

Preferred Name: Cantuzumab Ravtansine

Definition: An immunotoxin of a humanized monoclonal antibody C242 (MoAb HuC242) conjugated to a derivative of the cytotoxic agent maytansine, DM4, with potential antitumor activity. Cantuzumab ravtansine is generated from MoAb C242, which is raised against a cell surface superantigen, CA242, found in a variety of human tumor cells. Upon binding and entry, the immunoconjugate releases the maytansinoid agent DM4, which binds to tubulin, thereby affecting microtubule assembly/disassembly dynamics. As a result, this agent prevents cell division and reduces cell growth of cancer cells that express CA242.

NCI-GLOSS Definition: A substance being studied in the treatment of some types of cancer. It is made by linking the monoclonal antibody huC242 to a toxic substance called maytansinoid DM4. The monoclonal antibody binds to the surfaces of cancer cells and the maytansinoid DM4 enters the cells and blocks their growth. It is a type of immunotoxin.

Display Name: Cantuzumab Ravtansine

Label: Cantuzumab Ravtansine

NCI Thesaurus Code: C61576 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1831909  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Cantuzumab Ravtansine
CANTUZUMAB RAVTANSINE
huC242-DM4
HuC242-DM4
IMGN242
Maytansinoid DM4-Conjugated Humanized Monoclonal Antibody huC242
maytansinoid DM4-conjugated humanized monoclonal antibody huC242

External Source Codes: 
CAS Registry Number 868747-45-9 (see NLM ChemIDplus info)
FDA UNII Code RNQ8JQ4R9P
PDQ Closed Trial Search ID 492706
PDQ Open Trial Search ID 492706 (check for NCI PDQ open clinical trial info)
UMLS CUI C1831909

Other Properties:
     Name Value (qualifiers indented underneath)
code C61576
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name HuC242-DM4
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C61576

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