skip navigation links
National Cancer Institute
EVS Logo NCI Term Browser Enterprise Vocabulary Services
Terminologies Value Sets Mappings
Version: 17.06d (Release date: 2017-06-26)
SearchBox Top
SearchBox Bottom
Cantuzumab Ravtansine (Code C61576)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Cantuzumab Ravtansine

Definition: An immunotoxin of a humanized monoclonal antibody C242 (MoAb HuC242) conjugated to a derivative of the cytotoxic agent maytansine, DM4, with potential antitumor activity. Cantuzumab ravtansine is generated from MoAb C242, which is raised against a cell surface superantigen, CA242, found in a variety of human tumor cells. Upon binding and entry, the immunoconjugate releases the maytansinoid agent DM4, which binds to tubulin, thereby affecting microtubule assembly/disassembly dynamics. As a result, this agent prevents cell division and reduces cell growth of cancer cells that express CA242.

NCI-GLOSS Definition: A substance being studied in the treatment of some types of cancer. It is made by linking the monoclonal antibody huC242 to a toxic substance called maytansinoid DM4. The monoclonal antibody binds to the surfaces of cancer cells and the maytansinoid DM4 enters the cells and blocks their growth. It is a type of immunotoxin.

Display Name: Cantuzumab Ravtansine

Label: Cantuzumab Ravtansine

NCI Thesaurus Code: C61576 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1831909  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Cantuzumab Ravtansine
Maytansinoid DM4-Conjugated Humanized Monoclonal Antibody huC242
maytansinoid DM4-conjugated humanized monoclonal antibody huC242

External Source Codes: 
CAS Registry Number 868747-45-9 (see NLM ChemIDplus info)
PDQ Closed Trial Search ID 492706
PDQ Open Trial Search ID 492706 (check for NCI PDQ open clinical trial info)
UMLS CUI C1831909

Other Properties:
     Name Value (qualifiers indented underneath)
code C61576
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name HuC242-DM4
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


Mainbox Bottom