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Version: 17.12d (Release date: 2017-12-26)
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Lyso-Thermosensitive Liposome Doxorubicin (Code C61571)

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Terms & Properties

Preferred Name: Lyso-Thermosensitive Liposome Doxorubicin

Definition: A temperature-sensitive liposomal formulation of the anthracycline antibiotic doxorubicin with potential antineoplastic activity. Upon intravenous administration, circulating thermosensitive liposomes are activated locally by increasing the tumor temperature to 40-41 degrees Celsius using an external heat source. The elevated temperature causes compositional changes in the liposomes, creating openings that allow for the release of encapsulated doxorubicin. Compared to non-thermosensitive liposomes, lyso-thermosensitive liposomes deliver higher concentrations of a cytotoxic agent to a heat-treated tumor site while sparing normal tissues unexposed to heat treatment.

Display Name: Lyso-Thermosensitive Liposome Doxorubicin

Label: Lyso-Thermosensitive Liposome Doxorubicin

NCI Thesaurus Code: C61571 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1831903  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Heat-Activated Liposomal Doxorubicin Hydrochloride
Lyso-Thermosensitive Liposome Doxorubicin
Temperature Sensitive Liposome Encapsulated Doxorubicin

External Source Codes: 
PDQ Closed Trial Search ID 491935
PDQ Open Trial Search ID 491935 (check for NCI PDQ open clinical trial info)
UMLS CUI C1831903

Other Properties:
     Name Value (qualifiers indented underneath)
code C61571
Contributing_Source CTRP
Legacy_Concept_Name Lyso-Thermosensitive_Liposome_Doxorubicin
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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