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Version: 17.06d (Release date: 2017-06-26)
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Berubicin Hydrochloride (Code C61568)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Berubicin Hydrochloride

Definition: The hydrochloride salt of the anthracycline derivative berubicin with potential antineoplastic activity. Berubicin intercalates into DNA and interrupts topoisomerase II activity, resulting in the inhibition of DNA replication and repair, and RNA and protein synthesis. Unlike other anthracycline derivatives, this agent crosses the blood-brain barrier (BBB).

NCI-GLOSS Definition: A substance being studied in the treatment of adult brain tumors. RTA 744 crosses the blood-brain barrier and blocks an enzyme needed for cancer growth. It is a type of topoisomerase inhibitor.

Display Name: Berubicin Hydrochloride

Label: Berubicin Hydrochloride

NCI Thesaurus Code: C61568 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL364772  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
(8S,10S)-10-((3-amino-4-O-benzyl-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy)- 6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-7,8,9,10-tetrahydrotetracene-5,12-dione Hydrochloride
Berubicin Hydrochloride
BERUBICIN HYDROCHLORIDE
RTA 744
topoisomerase II inhibitor RTA 744
WP744

External Source Codes: 
CAS Registry Number 293736-67-1 (see NLM ChemIDplus info)
FDA UNII Code 7BA3X03948
PDQ Closed Trial Search ID 491929
PDQ Open Trial Search ID 491929 (check for NCI PDQ open clinical trial info)
NCI META CUI CL364772

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C34H35NO11.HCl
code C61568
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name RTA_744
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C61568

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