skip navigation links
National Cancer Institute
EVS Logo NCI Term Browser Enterprise Vocabulary Services
Terminologies Value Sets Mappings
Version: 16.11d (Release date: 2016-11-28)
SearchBox Top
SearchBox Bottom
Bendamustine Hydrochloride (Code C61565)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Bendamustine Hydrochloride

Definition: The hydrochloride salt of bendamustine, a bifunctional mechlorethamine derivative with alkylator and antimetabolite activities. Bendamustine possesses three active moieties: an alkylating group; a benzimidazole ring, which may act as a purine analogue; and a butyric acid side chain. Although its exact mechanism of action is unknown this agent appears to act primarily as an alkylator. Bendamustine metabolites alkylate and crosslink macromolecules, resulting in DNA, RNA and protein synthesis inhibition, and, subsequently, apoptosis. Bendamustine may differ from other alkylators in that it may be more potent in activating p53-dependent stress pathways and inducing apoptosis; it may induce mitotic catastrophe; and it may activate a base excision DNA repair pathway rather than an alkyltransferase DNA repair mechanism. Accordingly, this agent may be more efficacious and less susceptible to drug resistance than other alkylators.

NCI-GLOSS Definition: A drug used to treat chronic lymphocytic leukemia (CLL). It is also used to treat slow-growing B-cell non-Hodgkin lymphoma (NHL) that has gotten worse within 6 months of treatment with other anticancer drugs.It is being studied in the treatment of other types of cancer. Bendamustine hydrochloride may damage the DNA in cancer cells and cause them to die. It is a type of alkylating agent and a type of antimetabolite.

Display Name: Bendamustine Hydrochloride

Label: Bendamustine Hydrochloride

NCI Thesaurus Code: C61565 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0772139  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
2-Benzimidazolinebutryric acid, 1-methyl-5-bis(2-chloroethyl)amino-, hydrochloride
Bendamustine Hydrochloride
BENDAMUSTINE HYDROCHLORIDE
bendamustine hydrochloride
Bendamustin Hydrochloride
Cytostasan Hydrochloride
Levact
Ribomustin
SyB L-0501
Treanda

External Source Codes: 
CAS Registry Number 3543-75-7 (see NLM ChemIDplus info)
FDA UNII Code 981Y8SX18M
NSC Code 138783 (see NCI DTP info)
PDQ Closed Trial Search ID 350251
PDQ Open Trial Search ID 350251 (check for NCI PDQ open clinical trial info)
UMLS CUI C0772139

Other Properties:
Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For chronic lymphocytic leukemia
Chemical_Formula C16H21Cl2N3O2.ClH
code C61565
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Bendamustine_Hydrochloride
Semantic_Type Nucleic Acid, Nucleoside, or Nucleotide

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C61565

Mainbox Bottom