|Vinflunine (Code C61564)|
|Terms & Properties|
Preferred Name: Vinflunine
Definition: A bi-fluorinated derivative of the semi-synthetic vinca alkaloid vinorelbine with antitubulin, antineoplastic, and antiangiogenic activities. Vinflunine inhibits tubulin assembly without any stablization of assembled microtubules at concentrations comparable to those of other vinca alkaloids such as vincristine, vinblastine and vinorelbine; this effect on microtubule dynamics results in cell cycle arrest in mitosis and apoptosis. Compared to other vinca alkaloids, this agent binds weakly to the vinca-binding site, indicating that vinflunine may exhibit reduced neurotoxicity.
NCI-GLOSS Definition: A substance being studied in the treatment of bladder cancer, lung cancer, and other types of cancer.
Display Name: Vinflunine
NCI Metathesaurus Link: C0672663 (see NCI Metathesaurus info)
Synonyms & Abbreviations: (see Synonym Details)
External Source Codes:
|CAS Registry Number||162652-95-1 (see NLM ChemIDplus info)|
|FDA UNII Code||5BF646324K|
|PDQ Closed Trial Search ID||419548|
|PDQ Open Trial Search ID||419548 (check for NCI PDQ open clinical trial info)|
|Name||Value (qualifiers indented underneath)|
Additional Concept Data:
|Defined Fully by Roles: No|