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Version: 16.11d (Release date: 2016-11-28)
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Vinflunine (Code C61564)

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Terms & Properties

Preferred Name: Vinflunine

Definition: A bi-fluorinated derivative of the semi-synthetic vinca alkaloid vinorelbine with antitubulin, antineoplastic, and antiangiogenic activities. Vinflunine inhibits tubulin assembly without any stablization of assembled microtubules at concentrations comparable to those of other vinca alkaloids such as vincristine, vinblastine and vinorelbine; this effect on microtubule dynamics results in cell cycle arrest in mitosis and apoptosis. Compared to other vinca alkaloids, this agent binds weakly to the vinca-binding site, indicating that vinflunine may exhibit reduced neurotoxicity.

NCI-GLOSS Definition: A substance being studied in the treatment of bladder cancer, lung cancer, and other types of cancer.

Display Name: Vinflunine

Label: Vinflunine

NCI Thesaurus Code: C61564 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0672663  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
4'-Deoxy-20',20'-difluoro-C'-norvincaleukoblastine
Vinflunine
VINFLUNINE
vinflunine

External Source Codes: 
CAS Registry Number 162652-95-1 (see NLM ChemIDplus info)
FDA UNII Code 5BF646324K
PDQ Closed Trial Search ID 419548
PDQ Open Trial Search ID 419548 (check for NCI PDQ open clinical trial info)
UMLS CUI C0672663

Other Properties:
Name Value (qualifiers indented underneath)
Chemical_Formula C45H54F2N4O8
code C61564
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Vinflunine
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C61564

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