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Version: 17.06d (Release date: 2017-06-26)
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Recombinant Human Hyaluronidase (Code C61504)

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Terms & Properties

Preferred Name: Recombinant Human Hyaluronidase

Definition: A human recombinant form of the naturally occurring human enzyme hyaluronidase with potential chemoadjuvant activity. Upon local administration, recombinant human hyaluronidase hydrolyzes hyaluronic acid, a glucosaminoglycan responsible for the viscosity of the interstitial barrier. The digestion of hyaluronic acid lowers the viscosity in the interstitial space, thereby increasing permeability and facilitating local penetration of chemotherapeutic agents into cancer cells.

Display Name: Recombinant Human Hyaluronidase

Label: Recombinant Human Hyaluronidase

NCI Thesaurus Code: C61504 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1720035  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Chemophase
HYALURONIDASE (HUMAN RECOMBINANT)
Hyaluronidase Recombinant Human
Hylenex
Recombinant Human Hyaluronidase
rHuPH20

External Source Codes: 
CAS Registry Number 757971-58-7 (see NLM ChemIDplus info)
FDA UNII Code 743QUY4VD8
PDQ Closed Trial Search ID 486735
PDQ Open Trial Search ID 486735 (check for NCI PDQ open clinical trial info)
UMLS CUI C1720035

Other Properties:
     Name Value (qualifiers indented underneath)
code C61504
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Recombinant_Human_Hyaluronidase
Semantic_Type Enzyme
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C61504

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